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Cellular Forte Max

features an exclusive combination of IP-6 and Inositol, maitake D-fraction, and POA Cat's Claw, which support immune system health and healthy cell development.^†

HOW DOES IT WORK?
Inositol Hexaphosphate (IP-6) and Inositol
Both inositol hexaphosphate and inositol are naturally occurring compounds. Inositol is part of the B vitamin complex, and is found in both plant and animal cells.¹ Inositol hexaphosphate (IP-6 or phytic acid) is a component of fiber often found in grains and legumes. Its chemical structure is described as an inositol molecule with six phosphate groups (hexa=6) attached.² Inositol triphosphate (IP-3, or inositol bound to three phosphate groups) is the form of the compound that is believed to have the most beneficial health effects.^† However, IP-3 is not stable outside the body.^†³

Dr. A. Shamsuddin, a leading researcher in the field of IP-6 and inositol, patented the ratio of IP-6 to inositol found in Cellular Forté Max³. He hypothesizes that IP-6 functions by breaking down (dephosphorylation, or separation of the phosphate groups) into its more active forms, particularly IP-3. When IP-6 loses three phosphate groups it becomes IP-3. When inositol is given along with IP-6, it can accept (bind to) the phosphates that are liberated from the breakdown of IP-6. Inositol binding to three of the liberated phosphate groups forms another molecule of IP-3. In this way the levels of active IP-3 molecules are increased.⁴ Research suggests that IP-6, and its lower phosphorylated forms, help support healthy cell development.^†^5,6

Both the molecular ratio and the weight ratio of IP-6 to inositol are important in Cellular Forté Max³.

	Molecular Ratio	Weight
IP-6	1	400 mg
Inositol	1	110 mg

One molecule of IP-6 is four times the weight of an inositol molecule. A 1:1 molecular ratio, the ratio that yields maximum IP-3 production, is obtained by combining 400 mg IP-6 to 110 mg of inositol. Any variance from this 1:1 molecular ratio results in a significant reduction of IP-3 molecules produced.⁴ It is the molecular ratio, unique to the patent that distinguishes Cellular Forté^® Max³ from other products. Therefore, no other product can yield the optimal amount of IP-3 that Cellular Forté Max³ can deliver.^†

Research has demonstrated that IP-6 combined with inositol increases the activity of natural killer cells.^†^5,6 Natural killer (NK) cells are an important sub-population of circulating lymphocytes (white blood cells). The primary functions of NK cells are overall immune surveillance and immunoregulation. Increased NK cell often results enhanced support of healthy immune cells and healthy immune system function.^†

Maitake D-Fraction
Maitake (Grifola frondosa) mushrooms have a large fruiting body characterized by overlapping caps. Often referred to as Dancing Mushrooms or Hen-of-the-Woods, maitakes are popular edible mushrooms in Asia, especially Japan and China. Several maitake compounds have been identified, including the beta-glucan, maitake D-fraction. This branched polysaccharide has several immune health supportive functions.^†⁷

Specifically, maitake D-fraction supports healthy cell growth and function.^†^8,9 Maitake D-fraction also supports healthy natural killer cell development, macrophage activation, and cytotoxic T cell release.^† These actions, in turn, trigger production of interleukins and other lymphokines, chemicals that help mediate a healthy immune response.^† In published scientific studies, maitake d-fraction has been shown to have significant immune system effects.^†^10-13

POA Cat's Claw Root Extract
Cat's claw (Uncaria tomentosa) is native to the rainforest of Peru. The plant is a woody vine that climbs up and around tall rainforest trees, attaching itself to the trunk with curved cat-like claws located at the junction of leaves.^14,15 While the leaves, stem, and bark of Uncaria tomentosa have all been used as supplements for support of healthy immune function, only the root extracts of the plant have been scientifically identified and clinically studied.^† This is due to the presence of pentacyclic oxindole alkaloids (POAs) in cat's claw root extract.^16,17

Cat's claw POAs have important immune supportive health properties.^† Certain POAs increase the rate of macrophage phagocytosis and the production of interleukin secreted by macrophages.^† Cat's claw POAs also increase B cells, resulting in an increased supply of antibodies.^†^17-19

The POAs in cat's claw root extract also have immune-modulating effects.^† POAs support the release of mature cytotoxic CD8 T cells (killer T cells), mature CD4 T cells, and other mature T cells.^†^17-19 Release of immature cells, called lymphoblasts, actually reduces the effectiveness of the immune system response.^†²⁰ Cat's claw POAs support a balanced immune system and healthy immune response.^†^15-19 In unpublished studies, POA Cat's Claw has been shown to significantly support immune health in humans.^†^21-23

Cellular Forté Max³ is standardized to contain 1.3% pentacyclic oxindole alkaloids and to be free of tetracyclic oxindole alkaloids (TOAs). While POAs support immune health, tetracyclic oxindole alkaloids have decidedly different effects in the body, none supporting immune system cells.^†^24-26 Most importantly, however, when POAs and TOAs are mixed together, the TOAs work against the POAs. Even as little as 1% TOA content can cause POAs to lose their ability to beneficially support the immune system.^†^17,27 Additionally, the presence of TOAs may negate the effectiveness not only of the POAs of cat's claw, but of IP-6 with inositol as well.²⁸

Conclusion
The three ingredients in Cellular Forté Max³ all have scientifically demonstrated immune supportive effects, including support of healthy lymphocytes: B cells, helper T cells, killer T cells, suppressor T cells, neutrophils, and macrophages.^† It is theorized that when IP-6 and inositol, maitake mushrooms, and POA Cat's Claw Extract are combined they work synergistically to support healthy cell development.^†

The following chart details the immune supportive benefits of Cellular Forte^® Max³.

White Blood Cells	Cellular Forte^® Max³ Action
B Cells The major function of B cells is the production of antibodies in response to antigens (bacteria and viruses). Activated B cells mature into plasma cells, which produce thousands of antigen-specific antibodies per second. ^20,29	B cells exposed to Cell Forte Max3 ingredients demonstrated increased healthy cell activity, which resulted in healthy antibody production.^†¹⁷
Helper T Cells These T cells serve as the master switch for the immune system. Activated helper T cells (also known as CD4 cells) attract and activate B cells, killer T cells, macrophages, and other immune cells. ^20,29,30	Supports healthy proliferation of helper T cells and improves healthy communication of the immune system as a whole.^†^17,27
Killer T Cells Also referred as cytotoxic T cells or CD8 cells) killer T ells are alerted to the presence of antigens (bacteria, viruses, fungi, and tumor cells) by antigen glycoproteins. Once activated, killer T cells destroy targeted antigens by releasing lethal enzymes, and toxic cytokines. ^20,29	Supports the healthy proliferation of effective, mature T cells; supports healthy immune resistance response to antigens.^†^17,27
Suppressor T Cells Provide balance to the immune response. Suppressor T cells release biochemicals to alert the immune cells that the antigens have been destroyed.^20,30	Supports the healthy proliferation of mature suppressor T cells and supports healthy balance to the immune response.^†^17-19
Neutrophils Neutrophils are attracted to sites of injury and infection, where they engulf and digest (the process of phagocytosis) antigens (bacteria). The pus that forms in abscesses or other wounds, is made up of dead neutrophils and other cellular debris.^29,30	Supports the healthy production of neutrophils and supports the rate of healthy phagocytosis in the presence of antigens.^†¹⁷
Macrophages Macrophages have several immune functions. They secrete biochemicals that prime B cells and T cell activities. They also phagocytose antigens (virally infected cells and tumor cells) Some macrophages attach themselves to specific tissues and devote their immune efforts on site.²⁰	Supports the healthy secretion of macrophage-induced biochemical secretions and supports healthy macrophage production in the presence of antigens.^†^10,12,16,31
Natural Killer (NK) Cells In contrast to other white blood cells, NK cells do not require communication with other immune cells prior to activity. NK cells automatically kill antigens (tumor cells and virally infected cells). They continually perform overall surveillance and healthy immunoregulation.^20,29,30	Supports healthy activity of NK cells.^† Provides healthy support of immunoregulation and overall immune system surveillance.^†^5,6,31-35

RECOMMENDATIONS
Two UltraCaps^™ twice daily for maintenance. Best taken on an empty stomach. For maximum support, up to 16 UltraCaps may be taken per day.

PRECAUTIONS
If you are pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*The product you are requesting in part of our professional line that require pharmacist recommendation or practitioner referral. Please contact our pharmacy at 518/220-2005 or 800/890-1137 to request access information.